Osteocalcin is a protein found in bone and teeth. It is secreted by bone-building cells, called osteoblasts, and is deposited inside the bone matrix. Serum osteocalcin represents the fraction of the total produced that has not been placed inside the bone matrix.
Osteocalcin is often used as a biochemical marker, or biomarker, for the bone formation process. It has been routinely observed that higher serum osteocalcin levels are relatively well correlated with bone diseases characterized by increased bone turnover, especially osteoporosis.
In many studies, osteocalcin is used as a preliminary biomarker on the effectiveness of bisphosphonates, a class of drugs used to treat osteoporosis.
Fasting is not required for this test. Take all medications as prescribed.