Using state of the art technology known as nuclear magnetic resonance (NMR) spectroscopy, the NMR LipoProfile® is an advanced cholesterol test used to identify people at risk for lipid-related coronary heart disease (CHD).
The NMR® LipoProfile contains the following tests:
• LDL particle number (LDL-P)
• Small LDL particle number (small LDL-P)
• HDL particle number (HDL-P)
• LDL particle size
• A standard cholesterol test (LDL-C, HDL-C, triglycerides and total cholesterol)
LDL and HDL particles are the containers that transport cholesterol through your blood stream which can contribute to, or protect against atherosclerosis. Since LDL particles interact with the arterial wall as the beginning of the oxidation process that forms plaque, the higher number of LDL-P and small LDL-P, the greater the risk for CHD.1,2
On the other hand, a higher number of HDL-P is considered to be more protective, since HDL removes LDL by transporting it to the liver. In general, people with higher levels of HDL-P are at a lower risk for CHD. It is also well known that LDL particle size provides extremely important information on cardiovascular health. Small, dense LDL particles are dangerous since they contribute to plaque formation in the arterial wall. Ideally, one would want their results to show large, buoyant LDL particles. Small, dense particles are also closely associated with insulin resistance and an increased risk of developing type 2 diabetes. In addition to the particle size, the NMR LipoProfile® provides a laboratory developed index called LP-IR, with a higher number increasing the probability of developing insulin resistance.
Unfortunately, these vitally important markers contained in the NMR LipoProfile® are not included in the typical cholesterol test from your doctor. Standard lipid profiles utilize inferior technology and are limited to the use of cholesterol as a surrogate marker for your extremely important LDL particle number.1,2
Why use outdated technology when the NMR® LipoProfile can more accurately identify if you are really at risk for insulin resistance and CHD?
A 12-14 hour fast is required for this blood test. However, drink plenty of water and take your medications as prescribed.
- Cromwell WC, Otvos JD. Low-density lipoprotein particle number and risk for cardiovascular disease. Curr Athero Reports. 2004; 6:381-387.
- Otvos JD, Jeyarajah EF, Cromwell WC. Measurement issues related to lipoprotein hertogeneity. Amer J Cardiol. 2002;90(suppl):22i.