Prostatic acid phosphatase (PAP) is an enzyme that is found in the prostate gland and semen of men. If the prostate isn’t working properly, then PAP is released into the blood. PAP determination in conjunction with PSA measurements is useful in assessing the prognosis of prostate cancer.1,2Measurement of two markers allows identification of prostate cancer patients who have an elevation of PAP but not of PSA, and thus help monitoring the course of disease and response to treatment.
Fasting is not required for this test. Take all medications as prescribed.
Ejaculation within 48 hours preceding the blood draw may elevate the PSA in some men.
Powell P, Neal D, Gibb I, et al, “Immunologically Measured Serum Markers and Their Role in the Management of Prostate Cancer,” Eur Urol, 1988, 15(1-2):48-53. PubMed ID 2463921.
Han M, Piantadosi S, Zahurak ML, et al: Serum acid phosphatase level and biochemical recurrence following radical prostatectomy for men with clinically localized prostate cancer. Urology 57:707-11, 2001.
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