The serum protein electrophoresis (SPE) test measures specific proteins in the blood.
Blood serum contains two major protein groups: albumin and globulin. Using protein electrophoresis, these two groups can be separated into five smaller fractions:
- Alpha-1 globulin
- Alpha-2 globulin
- Beta globulin
- Gamma globulin
The primary use of this test is in the evaluation of multiple myeloma; a cancer of white blood cells responsible for producing antibodies. Symptoms of multiple myeloma include bone pain, anemia, fatigue, unexplained fractures, and/or recurrent infections,
Other applications of SPE include the following:
- Follow up when tests such as serum protein or calcium levels are abnormal
- Follow up to low white or red blood cell counts
- Symptoms of kidney or liver diseases
- Symptoms of autoimmune diseases
- Symptoms of inflammatory conditions
- Acute or chronic infections
Fasting is not required. Take all medications as prescribed.