Medications That Can Cause Acid Reflux: What You Need to Know

Acid reflux is often blamed on food—but for many people, the real trigger is hiding in their medicine cabinet. A wide range of commonly prescribed and over-the-counter medications are known to irritate the digestive tract, weaken the lower esophageal sphincter, or increase inflammation, all of which can worsen reflux symptoms.

Bone Medications and Acid Reflux

Bone drugs such as Fosamax and other bisphosphonates are well known for causing severe and sometimes dangerous acid reflux. These medications can irritate the esophagus and stomach lining, especially when taken long-term.

For individuals already dealing with heartburn, GERD, or sensitive digestion, these medications can significantly worsen symptoms—and in some cases, lead to lasting esophageal damage.

Blood Pressure Medications

Many blood pressure medications are also associated with acid reflux. While they play an important role in cardiovascular health, some can relax the valve between the stomach and esophagus, allowing acid to travel upward.

If reflux symptoms started or worsened after beginning a blood pressure medication, it’s worth having a conversation with your prescribing practitioner.

Anti-Anxiety and Psychiatric Medications

Medications such as Valium, Ativan, and Xanax are commonly prescribed for anxiety and stress, yet many people don’t realize these drugs can also contribute to acid reflux.

These medications can slow digestion and relax muscles that normally keep stomach acid where it belongs.

Pain Medications and Inflammation

Pain relievers—including familiar names like Advil and Motrin—are frequent triggers for reflux. Many pain medications irritate the stomach lining and increase digestive inflammation.

A simple but important concept to remember is this:

Where there is pain, there is inflammation.

When a drug suppresses inflammation, it can unintentionally disrupt the body’s natural protective mechanisms, increasing the risk of acid reflux and digestive discomfort.

What You Can Do

• Pay attention to when reflux symptoms started or worsened
• Review all prescription and over-the-counter medications you’re taking
• Talk with your healthcare provider about reflux-friendly alternatives
• Support digestion through diet, lifestyle, and mineral balance

Never stop a medication on your own—but always advocate for your digestive health. Sometimes a simple adjustment can make a meaningful difference.

Supporting Digestion Naturally

Many people find relief by supporting stomach function naturally through alkaline minerals, digestive-friendly nutrition, and addressing inflammation at its root rather than suppressing symptoms.

If you’re dealing with chronic reflux and taking long-term medications, a whole-body approach can help protect both your bones and your digestion.