How Buffered Ascorbate Can Help Relieve Your Allergies

How Buffered Ascorbate Can Help Relieve Your Allergies

Buffered ascorbate, our most potent form of vitamin C, is what we often refer to as the “maternal sacrificial antioxidant” because of its great role as an electron donor. Vitamin C, especially in buffered ascorbate form, readily donates electrons to free radicals and other molecules in need. Because of its potent antioxidant status, vitamin C serves many health-promoting roles in the body, one of which is anti-allergic.

In fact, researchers have documented that allergic diseases are associated with low plasma levels of ascorbate. Vitamin C is known as a natural antihistamine because it can block the secretion of histamine by white blood cells. Additionally, one study found that administration of 2 grams of vitamin C decreased histamine levels in the blood by 38%.  (1)

Intranasal ascorbate

In a clinical trial, allergic rhinitis (nasal congestion symptoms) was treated with an intranasal ascorbate solution 3x/day. After 2 weeks, 74% of the subjects treated with the ascorbate solution saw a decrease in nasal secretions, blockage, and edema. (2

Do you suffer from asthma?

A characteristic feature of asthma called mast-cell mediated bronchial hypersensitivity can be alleviated by vitamin C. (3)

Exercise and Vitamin C: A Match Made in Heaven

Vitamin C on its own has profound effects on allergy symptoms. Imagine what it can do combined with exercise! Tongtako et al. (4) investigated just that in their 2018 study. 27 subjects were studied. One group exercised, one group exercised and supplemented with 2 g of vitamin C, and the third group served as a control. After 8 weeks, the exercise + vitamin C group saw the most pronounced decrease in rhinitis symptoms such as nasal congestion, itching, and sneezing.

As Albert-Szent Györgi once said “A vitamin is a substance that makes you ill if you don’t eat it.” If you suffer from allergies, it would be in your best interest to take a deep dive into regaining optimal nutrition status. Given its natural antihistamine and anti-allergy functions, vitamin C may be a perfect place to start.


  1. Johnston, C. S., et al. 1992. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. Journal of the American College of Nutrition 11(2):172-176.
  2. Podoshin, L., et al. 1991. Treatment of perennial allergic rhinitis with ascorbic acid solution. Ear, Nose & Throat Journal 70(1):54-55.
  3. Shaik, Y. and P. Conti. 2016. Relationship between vitamin C, mast cells and inflammation. Journal of Nutrition & Food Sciences 6:1.
  4. Tongtako, W., et al. 2018. Effects of aerobic exercise and vitamin C supplementation on rhinitis symptoms in allergic rhinitis patients. Asian Pacific Journal of Allergy and Immunology 36(4):222-231.